Wetenschappelijke artikelen

2017

Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial

Tadesse FG, Lanke K, Nebie I, Schildkraut JA, Gonçalves BP, Tiono AB, Sauerwein R, Drakeley C, Bousema T, Rijpma SR
Am J Trop Med Hyg; 97(1):188-198.

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Age, weight, and CYP2D6 genotype are major determinants of primaquine pharmacokinetics in African children.

Gonçalves BP, Pett H, Tiono AB, Murry D, Sirima S, Niemi M, Bousema T, Drakeley C, Ter Heine R.
Antimicrob Agents Chemother. pii: AAC.02590-16.

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The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia


Malar J.;16(1):99

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2016

Mass Drug Administration for Malaria: A Means to What end?

Chen I, Gosling R, Drakeley C, Bousema T.
J Infect Dis. 214(12):1790-1792

In vivo efficacy of artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria: an open-randomized, non-inferiority clinical trial in South Kivu, Democratic Republic of Congo.

de Wit M, Funk AL, Moussally K, Nkuba DA, Siddiqui R, Bil K, Piriou E, Bart A, Bizoza PH, Bousema T
Malar J 15:455

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The effect of mass mosquito trapping on malaria transmission and disease burden (SolarMal): a stepped-wedge cluster-randomised trial.

Homan T, Hiscox A, Mweresa CK, Masiga D, Mukabana WR, Oria P, Maire N, Pasquale AD, Silkey M, Alaii J, Bousema T, Leeuwis C, Smith TA, Takken W.
Lancet. 2016. pii: S0140-6736(16)30445-7

Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression.

Lasonder E, Rijpma SR, van Schaijk BC, Hoeijmakers WA, Kensche PR, Gresnigt MS, Italiaander A, Vos MW, Woestenenk R, Bousema T, Mair GR, Khan SM, Janse CJ, Bártfai R, Sauerwein RW.
Nucleic Acids Res. pii: gkw536

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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

WWARN Gametocyte Study Group - Stepniewska & Bousema
BMC Medicine 14:79

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Heterogeneous malaria transmission in long-term Afghan refugee populations: a cross-sectional study in five refugee camps in northern Pakistan.

Wahid S, Stresman GH, Kamal SS, Sepulveda N, Kleinschmidt I, Bousema T, Drakeley C.
Malar J. ;15(1):245. doi: 10.1186/s12936-016-1305-7.

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The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial.

Bousema T*, Stresman G*, Baidjoe AY*, Bradley J, Knight P, Stone W, Osoti V, Makori E, Owaga C, Odongo W, China P, Shagari S, Doumbo OK, Sauerwein RW, Kariuki S, Drakeley C, Stevenson J#, Cox J#.
PLoS Med. 2016 Apr 12;13(4):e1001993

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Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial.

Gonçalves BP, Tiono AB, Ouédraogo A, Guelbéogo WM, Bradley J, Nebie I, Siaka D, Lanke K, Eziefula AC, Diarra A, Pett H, Bougouma EC, Sirima SB, Drakeley C*, Bousema T*
BMC Med. 2016 Mar 8;14(1):40.

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Genomic epidemiology of artemisinin resistant malaria

MalariaGEN Plasmodium falciparum Community Project
eLife 2016;5:e08714

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Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial.

Dicko A, Brown JM, Diawara H, Baber I, Mahamar A, Soumare HM, Sanogo K, Koita F, Keita S, Traore SF, Chen I, Poirot E, Hwang J, McCulloch C, Lanke K, Pett H, Niemi M, Nosten F, Bousema T*, Gosling R*.
Lancet Infect Dis. 2016. pii: S1473-3099(15)00479-X.

2015

Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies.

Slater HC, Ross A, Ouédraogo AL, White LJ, Nguon C, Walker PG, Ngor P, Aguas R, Silal SP, Dondorp AM, La Barre P, Burton R, Sauerwein RW, Drakeley C, Smith TA, Bousema T, Ghani AC.
Nature. 2015;528(7580):S94-S101.

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Dynamics of the Human Infectious Reservoir for Malaria Determined by Mosquito Feeding Assays and Ultrasensitive Malaria Diagnosis in Burkina Faso.

Ouédraogo AL, Gonçalves BP, Gnémé A, Wenger EA, Guelbeogo MW, Ouédraogo A, Gerardin J, Bever CA, Lyons H, Pitroipa X, Verhave JP, Eckhoff PA, Drakeley C, Sauerwein R, Luty AJ, Kouyaté B, Bousema T.
J Infect Dis. 2015; 213(1):90-9.

Submicroscopic carriage of Plasmodium falciparum and Plasmodium vivax in a low endemic area in Ethiopia where no parasitaemia was detected by microscopy or rapid diagnostic test.

Tadesse FG, Pett H, Baidjoe A, Lanke K, Grignard L, Sutherland C, Hall T, Drakeley C, Bousema T, Mamo H.
Malar J. 2015 Aug 5;14:303.

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data.

Worldwide Antimalarial Resistance Network (WWARN) AL Dose Impact Study Group.
Lancet Infect Dis. 2015 Jun;15(6):692-702.

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Stresman GH, Baidjoe AY, Stevenson J, Grignard L, Odongo W, Owaga C, Osoti V, Makori E, Shagari S, Marube E, Cox J, Drakeley C, Bousema T.

Stresman GH, Baidjoe AY, Stevenson J, Grignard L, Odongo W, Owaga C, Osoti V, Makori E, Shagari S, Marube E, Cox J, Drakeley C, Bousema T.
J Infect Dis. 2015;212(11):1768-77

Assessing the infectious reservoir of falciparum malaria: past and future.

Stone W, Gonçalves BP, Bousema T, Drakeley C.
Trends Parasitol. 2015; 31(7):287-96

Efficacy and safety of the mosquitocidal drug ivermectin to prevent malaria transmission after treatment: a double-blind, randomized, clinical trial.

Ouédraogo AL, Bastiaens GJ, Tiono AB, Guelbéogo WM, Kobylinski KC, Ouédraogo A, Barry A, Bougouma EC, Nebie I, Ouattara MS, Lanke KH, Fleckenstein L, Sauerwein RW, Slater HC, Churcher TS, Sirima SB, Drakeley C, Bousema T.
Clin Infect Dis. 2015 Feb 1;60(3):357-65.

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Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis.

Okell LC, Cairns M, Griffin JT, Ferguson NM, Tarning J, Jagoe G, Hugo P, Baker M, D'Alessandro U, Bousema T, Ubben D, Ghani AC.
Nat Commun. 2014 Nov 26;5:5606

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Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.

White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, Mayxay M, Taylor WR, von Seidlein L, Price RN, Barnes KI, Djimdé A, ter Kuile F, Gosling R, Chen I, Dhorda MJ, Stepniewska K, Guérin P, Woodrow CJ, Dondorp AM, Day NP, Nosten FH.
Malar J. 2014 Dec 9;13:483. doi: 10.1186/1475-2875-13-483.

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Infectiousness of the human population to Anopheles arabiensis by direct skin feeding in an area hypoendemic for malaria in Senegal.

Gaye A, Bousema T, Libasse G, Ndiath MO, Konaté L, Jawara M, Faye O, Sokhna C
Am J Trop Med Hyg. 2015 Mar;92(3):648-52.

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Asymptomatic malaria infections: detectability, transmissibility and public health relevance.

Bousema T, Okell L, Felger I, Drakeley C.
Nature Rev Microbiol. 2015;12(12):833-40

Efficacy and Safety of Triple Combination Therapy With Artesunate-Amodiaquine-Methylene Blue for Falciparum Malaria in Children: A Randomized Controlled Trial in Burkina Faso.

Coulibaly B, Pritsch M, Bountogo M, Meissner PE, Nebié E, Klose C, Kieser M, Berens-Riha N, Wieser A, Sirima SB, Breitkreutz J, Schirmer RH, Sié A, Mockenhaupt FP, Drakeley C, Bousema T, Müller O.
J Infect Dis. 2015; 211(5):689-97

2014

Modeling the cost effectiveness of malaria control interventions in the highlands of Western kenya.

Stuckey EM, Stevenson J, Galactionova K, Baidjoe AY, Bousema T, Odongo W, Kariuki S, Drakeley C, Smith TA, Cox J, Chitnis N.
PLoS One. 9: e10770

The Potential Impact of Adding Ivermectin to a Mass Treatment Intervention to Reduce Malaria Transmission: a Modelling Study.

Slater HC, Walker PG, Bousema T, Okell LC, Ghani AC.
J Infect Dis. 2014; 210(12):1972-80

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Low-dose primaquine for falciparum malaria.

Bousema T, Eziefula AC, Pett H, Drakeley C
Lancet Infect Dis. 14(8):677

Directional selection at the pfmdr1, pfcrt, pfubp1 and pfap2mu loci of Plasmodium falciparum in Kenyan children treated with ACT.

Henriques G, Hallett RL, Beshir KB, Gadalla NB, Johnson RE, Burrow R, van Schalkwyk DA, Sawa P, Omar SA, Clark TG, Bousema T, Sutherland CJ.
J Infect Dis. pii: jiu358

Quantifying travel behavior for infectious disease research: a comparison of data from surveys and mobile phones.

Wesolowski A, Stresman G, Eagle N, Stevenson J, Owaga C, Marube E, Bousema T, Drakeley C, Cox J, Buckee CO.
Sci Rep. 4:5678.

G6PD status and risk of haemolysis in African P. falciparum infected children receiving single-dose primaquine.

Eziefula AC, Pett H, Grignard L, Opus S, Kiggundu M, Kamya MR, Yeung S, Staedke SG, Bousema T, Drakeley C.
Antimicrob Agents Chemother pii: AAC.02889-14

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains.

Preston MD, Campino S, Assefa SA, Echeverry DF, Ocholla H, Amambua-Ngwa A, Stewart LB, Conway DJ, Borrmann S, Michon P, Zongo I, Ouédraogo JB, Djimde AA, Doumbo OK, Nosten F, Pain A, Bousema T, Drakeley CJ, Fairhurst RM, Sutherland CJ, Roper C, Clark TG.
Nat Commun. 5:4052

A scalable assessment of Plasmodium falciparum transmission in the standard membrane feeding assay using transgenic parasites expressing GFP-luciferase.

Stone WJ, Churcher TS, Graumans W, van Gemert GJ, Vos MW, Lanke KH, van de Vegte-Bolmer MG, Siebelink-Stoter R, Dechering KJ, Vaughan AM, Camargo N, Kappe SH, Sauerwein RW, Bousema T.
J Infect Dis. 2014;210(9):1456-63

Validation of three geolocation strategies for health-facility attendees for research and public health surveillance in a rural setting in western Kenya

Stresman GH, Stevenson JC, Owaga C, Marube E, Anyano C, Drakeley C, Bousema T, Cox J.
Epidemiology & Infection; 1: 1-12

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A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots

Bejon P, Williams TN, Nyundo C, Hay SI, Benz D, Gething PW, Otiende M, Peshu J, Bashraheil M, Greenhouse B, Bousema T, Bauni E, Marsh K, Smith DL, Borrmann S
Elife;3:e02130

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Hot spot or not: a comparison of spatial statistical methods to predict prospective malaria infections.

Mosha JF, Sturrock HJ, Greenwood B, Sutherland CJ, Gadalla NB, Atwal S, Hemelaar S, Brown JM, Drakeley C, Kibiki G, Bousema T, Chandramohan D, Gosling RD.
Malar J. 13: 53.

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A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages.

Theisen M, Roeffen W, Singh SK, Andersen G, Amoah L, van de Vegte-Bolmer M, Arens T, Tiendrebeogo RW, Jones S, Bousema T, Adu B, Dziegiel MH, Christiansen M, Sauerwein R.
Vaccine 32 :2623-30.

Is Housing Quality Associated with Malaria Incidence among Young Children and Mosquito Vector Numbers? Evidence from Korogwe, Tanzania.

Liu JX, Bousema T, Zelman B, Gesase S, Hashim R, Maxwell C, Chandramohan D, Gosling R
PLoS One. 9(2):e87358

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Measuring Changes in Plasmodium falciparum Transmission: Precision, Accuracy and Costs of Metrics.

Tusting LS, Bousema T, Smith DL, Drakeley C.
Adv Parasitol. 84:151-208

Scale-up of Malaria Rapid Diagnostic Tests and Artemisinin-Based Combination Therapy: Challenges and Perspectives in Sub-Saharan Africa.

Bastiaens GJ, Bousema T, Leslie T.
PLoS Med. 11(1):e1001590.

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PlasmoView: A web-based resource to visualise global Plasmodium falciparum genomic variation.

Preston MD, Assefa SA, Ocholla H, Sutherland CJ, Borrmann S, Nzila A, Michon P, Hien TT, Bousema T, Drakeley CJ, Zongo I, Ouédraogo JB, Djimde AA, Doumbo OK, Nosten F, Fairhurst RM, Conway DJ, Roper C, Clark TG.
J Infect Dis.

Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial.

Eziefula AC, Bousema T, Yeung S, Kamya M, Owaraganise A, Gabagaya G, Bradley J, Grignard L, Lanke KH, Wanzira H, Mpimbaza A, Nsobya S, White NJ, Webb EL, Staedke SG, Drakeley C.
Lancet Infect. Dis.;14(2):130-9.

2013

The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin-piperaquine: a pooled analysis of individual patient data.

WorldWide Antimalarial Resistance Network (WWARN) DP Study Group.
PLoS Med.;10(12):e1001564

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The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays.

Stone WJ, Eldering M, van Gemert GJ, Lanke KH, Grignard L, van de Vegte-Bolmer MG, Siebelink-Stoter R, Graumans W, Roeffen WF, Drakeley CJ, Sauerwein RW, Bousema T.
Nature Sci Rep. 3:3418.

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Reliability of School Surveys in Estimating Geographic Variation in Malaria Transmission in the Western Kenyan Highlands

Stevenson JC, Stresman GH, Gitonga C, Gillig J, Owaga C, Marube E, Odongo W, Okoth A, China P, Oriango R, Brooker SJ, Bousema T, Drakeley C, Cox J.
PLoS ONE 2013; 8: e77641

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Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence.

Beshir KB, Sutherland CJ, Sawa P, Drakeley CJ, Okell L, Mweresa CK, Omar SA, Shekalaghe SA, Kaur H, Ndaro A, Chilongola J, Schallig HD, Sauerwein RW, Hallett RL, Bousema T.
J Infect Dis. 2013 Aug 14

The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa.

Okombo J, Zongo I, Gadalla N, Bousema T, Beshir KB, Roper C, Hallett R, Ochola-Oyier LI, Sutherland CJ.
Antimicrob Agents Chemother. 2013; 57: 4595-8

Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics.

Mosha JF, Sturrock HJ, Greenhouse B, Greenwood B, Sutherland CJ, Gadalla N, Atwal S, Drakeley C, Kibiki G, Bousema T, Chandramohan D, Gosling R.
Malar. J. 2013; 12: 221

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Targeting asymptomatic malaria infections: active surveillance in control and elimination.

Sturrock HJ, Hsiang MS, Cohen JM, Smith DL, Greenhouse B, Bousema T, Gosling RD
PLos Med 2013; 10: e1001467

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Combined DNA extraction and antibody elution from filter papers for the assessment of malaria transmission intensity in epidemiological studies.

Baidjoe A, Stone W, Ploemen I, Shagari S, Grignard L, Osoti V, Makori E, Stevenson J, Kariuki S, Sutherland C, Sauerwein R, Cox J, Drakeley C, Bousema T.
Malar. J. 2013; 12: 272

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Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection.

Churcher TS, Bousema T, Walker M, Drakeley C, Schneider P, Ouédraogo AL, Basáñez MG.
Elife. 2013;2:e0062

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Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination.

Chaccour CJ, Kobylinski KC, Bassat Q, Bousema T, Drakeley C, Alonso P, Foy BD.
Malar J. 2013;12:153

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The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial.

Bousema T, Stevenson J, Baidjoe A, Stresman G, Griffin JT, Kleinschmidt I, Remarque EJ, Vulule J, Bayoh N, Laserson K, Desai M, Sauerwein R, Drakeley C, Cox J.
Trials. 2013;14:36

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Malaria Transmission After Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine: A Randomized Trial.

Sawa P, Shekalaghe SA, Drakeley CJ, Sutherland CJ, Mweresa CK, Baidjoe AY, Manjurano A, Kavishe RA, Beshir KB, Yussuf RU, Omar SA, Hermsen CC, Okell L, Schallig HD, Sauerwein RW, Hallett RL, Bousema T.
J Infect Dis 2013

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Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda.

Proietti C, Verra F, Bretscher MT, Stone W, Kanoi BN, Balikagala B, Egwang TG, Corran P, Ronca R, Arcà B, Riley EM, Crisanti A, Drakeley C, Bousema T.
Parasite Immunol. 2013

Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda.

Eziefula AC, Staedke SG, Yeung S, Webb E, Kamya M, White NJ, Bousema T, Drakeley C.
BMJ Open 2013;26:3

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Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions?

Bousema T, Churcher TS, Morlais I, Dinglasan RR
Trends Parasitol. 2013;29:53-9

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2012

Investigation of outbreaks complicated by universal exposure.

Tostmann A, Bousema T, Oliver I
Emerg Infect Dis 2012; 18:1717-22

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Rationale for short course primaquine in Africa to interrupt malaria transmission.

Eziefula AC, Gosling R, Hwang J, Hsiang MS, Bousema T, von Seidlein L, Drakeley C
Malar J. 2012; 11: 360

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Factors determining the occurrence of submicroscopic malaria infections and their relevance for control

Okell LC, Bousema T, Griffin JT, Ouédraogo AL, Ghani AC, Drakeley CJ.
Nature Communications 2012; 3:1237

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Duration of the mosquitocidal effect of ivermectin

Bastiaens GJH, van Gemert GJ, Hooghof J, Lindsay SW, Drakeley C, Churcher TS, Verhave JP, Cocken CHM, Sauerwein RW, Bousema T
Malaria World Journal 2012; 3:10

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IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk.

Stone W, Bousema T, Jones S, Gesase S, Hashim R, Gosling R, Carneiro I, Chandramohan D, Theander T, Ronca R, Modiano D, Arcà B, Drakeley C.
PLoS ONE. 2012;7:e40170.

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Filter paper collection of Plasmodium falciparum mRNA for detecting low-density gametocytes.

Jones S, Sutherland CJ, Hermsen C, Arens T, Teelen K, Hallett R, Corran P, van der Vegte-Bolmer M, Sauerwein R, Drakeley CJ, Bousema T.
Malar J. 2012; 11:266.

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Mosquito Feeding Assays to Determine the Infectiousness of Naturally Infected Plasmodium falciparum Gametocyte Carriers.

Bousema T, Dinglasan RR, Morlais I, Gouagna LC, van Warmerdam T, Awono-Ambene PH, Bonnet S, Diallo M, Coulibaly M, Tchuinkam T, Mulder B, Targett G, Drakeley C, Sutherland C, Robert V, Doumbo O, Touré Y, Graves PM, Roeffen W, Sauerwein R, Birkett A, Locke E, Morin M, Wu Y, Churcher TS.
PLoS ONE. 2012

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Hitting hotspots: spatial targeting of malaria for control and elimination.

Bousema T, Griffin JT, Sauerwein RW, Smith DL, Churcher TS, Takken W, Ghani A, Drakeley C, Gosling R.
PLoS Med. 2012; 9: e1001165

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2011

Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities.

Oguike MC, Betson M, Burke M, Nolder D, Stothard JR, Kleinschmidt I, Proietti C, Bousema T, Ndounga M, Tanabe K, Ntege E, Culleton R, Sutherland CJ.
Int J Parasitol. 2011;41:677-83.

Malaria diagnostic testing and treatment practices in three different Plasmodium falciparum transmission settings in Tanzania: before and after a government policy change.

Bastiaens GJ, Schaftenaar E, Ndaro A, Keuter M, Bousema T, Shekalaghe SA.
Malar J. 2011;10:76.

Continuing intense malaria transmission in northern Uganda.

Proietti C, Pettinato DD, Kanoi BN, Ntege E, Crisanti A, Riley EM, Egwang TG, Drakeley C, Bousema T.
Am J Trop Med Hyg. 2011;84:830-7.

A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania.

Shekalaghe SA, Drakeley C, van den Bosch S, ter Braak R, van den Bijllaardt W, Mwanziva C, Semvua S, Masokoto A, Mosha F, Teelen K, Hermsen R, Okell L, Gosling R, Sauerwein R, Bousema T.
Malar J. 2011;10:247.

The potential contribution of mass treatment to the control of Plasmodium falciparum malaria.

Okell LC, Griffin JT, Kleinschmidt I, Hollingsworth TD, Churcher TS, White MJ, Bousema T, Drakeley CJ, Ghani AC.
PLoS ONE. 2011;6:e20179.

Naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs48/45 and Pfs230 in an area of seasonal transmission.

Ouédraogo AL, Roeffen W, Luty AJ, de Vlas SJ, Nebie I, Ilboudo-Sanogo E, Cuzin-Ouattara N, Teleen K, Tiono AB, Sirima SB, Verhave JP, Bousema T, Sauerwein R.
Infect Immun. 2011;79:4957-64.

A research agenda for malaria eradication: basic science and enabling technologies. malERA Consultative Group on Basic Science and Enabling Technologies.

Baum J, Billker O, Bousema T, Dinglasan R, McGovern V, Mota MM, Mueller I, Sinden R.
PLoS Med. 2011;8:e1000399.

Human immune responses that reduce the transmission of Plasmodium falciparum in African populations.

Bousema T, Sutherland CJ, Churcher TS, Mulder B, Gouagna LC, Riley EM, Targett GA, Drakeley CJ.
Int J Parasitol. 2011;41:293-300.

The dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in Tanzania.

Bousema T, Roeffen W, Meijerink H, Mwerinde H, Mwakalinga S, van Gemert GJ, van de Vegte-Bolmer M, Mosha F, Targett G, Riley EM, Sauerwein R, Drakeley
PLoS ONE. 2010;5:e14114.

Adjusting for heterogeneity of malaria transmission in longitudinal studies.

Bousema T, Kreuels B, Gosling R.
J Infect Dis. 2011;204:1-3.

Plasmodium falciparum and Plasmodium vivax gametocytes – their epidemiology and infectivity in relation to malaria control and elimination.

Bousema T, Drakeley C.
Clin Microbiol Rev 2011; 24:1-35.

2010

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs.

Bousema T, Okell L, Shekalaghe S, Griffin JT, Omar S, Sawa P, Sutherland C, Sauerwein R, Ghani AC, Drakeley C.
Malar J. 2010;9:136.

Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies.

Griffin JT, Hollingsworth TD, Okell LC, Churcher TS, White M, Hinsley W, Bousema T, Drakeley CJ, Ferguson NM, Basáñez MG, Ghani AC.
PLoS Med. 2010;7(8): e1000324.

The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina Faso.

Ouédraogo AL, Bousema T, de Vlas SJ, Cuzin-Ouattara N, Verhave JP, Drakeley C, Luty AJ, Sauerwein R.
Malar J. 2010;9:281.

In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.

Shekalaghe SA, ter Braak R, Daou M, Kavishe R, van den Bijllaardt W, van den Bosch S, Koenderink JB, Luty AJ, Whitty CJ, Drakeley C, Sauerwein RW, Bousema T.
Antimicrob Agents Chemother. 2010;54:1762-8.

Serologic markers for detecting malaria in areas of low endemicity, Somalia, 2008.

Bousema T, Youssef RM, Cook J, Cox J, Alegana VA, Amran J, Noor AM, Snow RW, Drakeley C.
Emerg Infect Dis. 2010;16:392-9.

Identification of hot spots of malaria transmission for targeted malaria control.

Bousema T, Drakeley C, Gesase S, Hashim R, Magesa S, Mosha F, Otieno S, Carneiro I, Cox J, Msuya E, Kleinschmidt I, Maxwell C, Greenwood B, Riley E, Sauerwein R, Chandramohan D, Gosling R.
J Infect Dis. 2010;201:1764-74.

Tot 2009, een selectie van publicaties

Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection.

Bousema JT, Schneider P , Gouagna LC, Otieno S, van de Vegte-Bolmer M, Omar SA, Sauerwein RW.
Am J Trop Med Hyg. 2007;76:470-4.

Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission.

Ouédraogo AL, Bousema T, Schneider P, de Vlas S, Ilboudo-Sanogo E, Cuzin-Ouattara N, Nébié I, Roeffen W, Verhave JP, Luty AF, Sauerwein RW.
PLoS ONE 2009; e8410.

Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate.

Shekalaghe S, Drakeley C, Gosling R, Ndaro A, van Meegeren M, Enevold A, Alifrangis M, Mosha F, Sauerwein R, Bousema T.
PLoS ONE 2007; 2:e1023.

Sexual-stage antibody responses to P. falciparum in endemic populations.

Bousema T, Drakeley CJ, Sauerwein RW.
Curr Mol Med. 2006;6:223-9.

The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion.

Drakeley C, Sutherland C, Bousema JT, Sauerwein RW, Targett GAT.
Trends Parasitol. 2006;22:424-30.

Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum.

Bousema JT, Schneider P, Gouagna LC, Drakeley CJ, Tostmann A, Houben R, Githure JI, Ord R, Sutherland CJ, Omar SA, Sauerwein RW.
J Infect Dis. 2006;193:1151-9.

Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity.

Okell LC, Drakeley CJ, Bousema T, Whitty CJ, Ghani AC.
PLoS Med. 2008;5:e226.